Crosslinking Reagents
Medchemexpress LLC Sulfo-LC-SPDP sodium | 169751-10-4 | 527.57 | C18H22N3NaO8S3 | 10 MG
Sulfo-LC-SPDP sodium is a thiol-cleavable, heterobifunctional linker used to conjugate payloads to antibodies via a disulfide bond. It provides a water-soluble long-chain spacer and a pyridinyldithiol reactive group to enable payload release under reducing conditions. Intended for research use only.
- cleavable disulfide linker for controlled payload release
- heterobifunctional reactivity for amine and thiol conjugation
- water-soluble sodium salt for improved aqueous handling
- long-chain spacer reduces steric hindrance at the conjugation site
- suitable for antibody-drug conjugate synthesis and bioconjugation workflows
- molecular weight 527.57 and formula C18H22N3NaO8S3
Medchemexpress LLC PC SPDP-NHS carbonate ester | 2279944-61-3 | MFCD31811480 | 95.0% | 608.64 | C25H28N4O10S2 | 5 MG
PC SPDP-NHS carbonate ester is a photocleavable carbonate NHS ester linker used for bioconjugation and the construction of antibody-drug conjugates (ADCs). It provides an NHS carbonate reactive site for coupling to primary amines and a photolabile unit that enables controlled payload release.
- Cleavable photocleavable linker suitable for ADC synthesis
- Contains an NHS carbonate reactive group for amine conjugation
- Purity 95.0%
- Molecular weight 608.64
- Soluble in common organic solvents such as DMSO
- Supplied in small research pack sizes for laboratory use
Medchemexpress LLC DTME 5mg
DTME (dithio-bis-maleimidoethane) is a homobifunctional maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH) DTME whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917) DTME is commonly utilized to explore and characterize protein structure particularly oligomerization or protein interactions[1]
Medchemexpress LLC DBCO-Sulfo-Link-biot 5mg
DBCO-Sulfo-Link-biotin TEA is a click chemistry intermediate containing a DBCO group which can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group
Cayman Chemical SulfosuccInImIdyl 32 BIot 50mg
An amine-reactive reagent; has been used as a derivatization reagent to identify PTMs in lysine-rich proteins and novel cell surface proteins of R. rickettsii
Medchemexpress LLC BS3 crosslinker disodium | 127634-19-9 | 98.0% | 572.43 g/mol | C16H18N2Na2O14S2 | 25 MG
BS3 crosslinker disodium is a water-soluble, non-cleavable homobifunctional crosslinker with sulfo-NHS ester reactive groups and an 8-carbon spacer. It targets primary amines to form stable amide bonds, enabling efficient protein-protein crosslinking and antibody-drug conjugate synthesis in aqueous conditions. The reagent is provided as a sodium salt and is suitable for bioconjugation, analytical crosslinking, and ADC linker applications.
- Water-soluble, compatible with aqueous reactions.
- Reacts with primary amines to form stable amide bonds.
- Non-cleavable linker for stable conjugates.
- Sulfo-NHS ester groups enable efficient coupling at physiological pH.
- High purity supports reproducible bioconjugation.
- Soluble in DMSO and tested in common in vivo vehicle systems.
- Stable when stored sealed at low temperatures away from moisture and light.
FOCUS BIOMOLECULES Biochemical Reagents, Mitomycin C, DNA crosslinking and damaging agent, CAS 50-07-7, 98% by TLC/NMR Conforms
Biochemical Reagents, Mitomycin C, DNA crosslinking and damaging agent, CAS 50-07-7, 98% by TLC/NMR Conforms, DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable.This product is not approved for human therapeutic use.
Abcam Disuccinimidyl suberate, cross-linking reagent, 500MG
MW 368.34 Da, Purity >99%. Homobifunctional primary amine reactive cross-linker. Contains an 8 atom linker (11.4 Å) and can cross-link distances up to ~25 Å due to protein flexibility. Produces no toxic side products.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Disuccinimidyl suberate, cross-linking reagent, 1G
MW 368.34 Da, Purity >99%. Homobifunctional primary amine reactive cross-linker. Contains an 8 atom linker (11.4 Å) and can cross-link distances up to ~25 Å due to protein flexibility. Produces no toxic side products.
The product is subject to the following: Abcam Restricted Use Statement